April is Bowel Cancer Awareness Month

In recognition of April being Bowel Cancer Awareness month, the Cancer Research UK Oxford Centre will be posting a series of blog posts on its website highlighting the contribution of Oxford researchers to global efforts aiming to tackle colorectal cancer.

Colorectal cancer is one of the most common cancers, affecting over 40,000 people per year in the UK. Sadly, it remains one of the most common causes of cancer death, despite the fact that the condition could be preventable. Almost all colorectal cancer develops from benign precursors called polyps or adenomas, and these lesions are detectable and safely removeable by an endoscopic procedure. It is this potential for prevention that led to the roll out of the national bowel cancer screening service in 2006.

Genomic investigation and biological models, such as organoids, have rapidly accelerated our understanding of colorectal cancer initiation and development in the last 15 years, and this understanding opens the way for new treatments and detection methods.

Colorectal cancer is an area of intense research activity in Oxford, and is a cornerstone of our early detection programme. Oxford researchers undertake international quality work on the basic, translational and clinical science of genetic predisposition, stem cells microenvironmental risk, the impact of the immune system, molecular and morphological stratification, new drugs and treatments and endoscopic detection.

This series of articles will summarise some of the local and national projects our researchers are leading on and contributing to, including:

 

 

 

 

 

 

Prof. Simon Leedham – Wellcome Trust Senior Research Fellow in Clinical Science and an Honorary Consultant Gastroenterologist, Head of Leedham Group