Entries by Oxford Centre

Pioneering Combination Therapy Approach to Treating Colorectal Cancer

Celleron Therapeutics, the UK-based company and Oxford University spin-out developing personalised medicine for cancer patients, has today announced the initiation and first patient enrolment of its clinical study that will evaluate the effect of a novel combination therapy approach for colorectal cancer. Professor Mark Middleton, Consultant Medical Oncologist and Professor of Experimental Cancer Medicine at […]

Rare cancer could be caught early using simple blood tests

A pioneering study into myeloma, a rare cancer, could lead to GPs using simple blood tests to improve early diagnosis. CRUK Centre members, in collaboration with the University of Exeter and Chiddenbrook Surgery, Crediton, found that a simple combination of blood tests, which are routinely conduced in GP surgeries, could improve early diagnosis of myeloma. […]

Oxford researchers discover DNA repair protein complex important in drug resistance in cancers driven by BRCA mutations.

A team of Cancer Centre researchers lead by Associate Professor Ross Chapman have discovered a novel DNA repair protein complex called ‘Shieldin’. Published in Nature, the paper describes the identification of ‘Shieldin’, which was shown to be essential for generating genetic diversity in antibodies produced during immune responses. When activated following an infection or immunisation, B […]

Focussed ultrasound and nanomedicine offer new hope for improving effects of cancer drugs

Researchers have made a breakthrough in more precisely targeting drugs to cancers. A number of Centre members were part of a multi-disciplinary team of biomedical engineers, oncologists, radiologists and anaesthetists that have used ultrasound and lipid drug carriers (liposomes) to improve the targeting of cancer drugs to a tumour. The new technology has been used […]

Prognostic biomarkers discovered for patients with malignant pleural effusion

In a collaboration spanning multiple departments within Oxford and beyond, Centre members led by Dr Ioannis Psallidas have developed a new risk score (PROMISE score) that can provide important information on patient prognosis, and guide the selection of appropriate management strategies for patients with malignant pleural effusion. Malignant pleural effusion is defined as the accumulation […]

Aspirin and acid reflux medication reduce the likelihood of patients with Barrett’s oesophagus developing oesophageal cancer.

Results of the AspECT clinical trial, coordinated by the CRUK Oxford Centre supported Oncology Clinical Trials Office, have shown the important role aspirin and acid reflux treatment can have in preventing those at high risk of oesophageal cancer from going on to develop the disease. The trial led by Professor Janusz Jankowski had results presented […]

Simon Leedham awarded the Cancer Research UK Future Leaders in Cancer Research Prize

Today at the NCRI Annual Conference Professor Simon Leedham was awarded the Cancer Research UK Future Leaders in Cancer Research Prize. Simon is a Cancer Research UK Clinician Scientist Fellow at the Wellcome Trust Centre for Human Genetics. His research has made important advances in the cell biology and molecular pathogenesis of gastrointestinal cancers and […]