Previous awards
The Centre’s unique scheme to provide pump-priming funds to support collaborative projects in cancer research has been a key area of activity. The scheme has proved an exceptionally useful tool in supporting the development of the Centre, and bringing the research community together.
Over the past six years the Centre has awarded over £2.3m across 170 projects and 185 principle investigators. Though still in its early stages, this investment has already yielded over £15 million in external grant funding, more than 80 publications, presentations or manuscripts, and seeded nearly 160 new collaborations nationally and internationally.
Previous Development Fund recipients are highlighted below:
January 2019
Dr Lynn Quek, MRC MHU, Weatherall Institute of Molecular Medicine
Single cell transcriptomic and proteomic analysis of granulocyte-monocyte and erythroid differentiation in normal haematopoietic progenitors and in Acute Myeloid Leukaemia.
Dr Gillian Farnie, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences
Investigating tumour heterogeneity to discover mechanisms of inherent and therapy induced resistance
Prof. Anne Kiltie, CRUK/MRC Oxford Institute of Radiation Oncology
Development of a human gastrointestinal epithelial organoid assay to identify non-toxic chemoradiation combinations for abdominal and pelvic tumours
Dr Shivan Sivakumar, Department of Oncology
Mapping the T cell architecture of pancreatic cancer
Dr Natalia Gromak, Sir William Dunn School of Pathology
Molecular Mechanism of APOBEC3B-Dependent targeting of pathological R loops in breast cancer
Dr Benjamin Schuester-Bockler, Nuffield Department of Medicine, Big Data Institute
Determining the mechanism of mutagenesis in gastric and oesophageal adenocarcinomas
Dr Jacqueline Boultwood, Nuffield Division of Clinical Laboratory Sciences
Single-cell analysis of haematopoietic stem cells in advanced myelodysplastic syndromes: identification of new therapeutic treatments/targets
Dr Jordan Becker, Wellcome Centre for Human Genetics
Dissecting the mechanism of BRCA1-BARD1 complex function in DNA double-strand break repair
Dr Jan Bornschein, Translational Gastroenterology Unit
Transcriptome profiling of different stages of inflammatory, preneoplastic, and neoplastic alterations of the gastric mucosa by RNA-sequencing. Analysis of risk-factor associated gene expression signatures and virtual microdissection to enable analysis of epithelial-stromal interaction.
Dr Fumiko Esahi, Sir William Dunn School of Pathology
Exploring the role of BRCA1 AND PALB2 in myeloid differentiation
Prof Sarah Blagden, Department of Oncology
The Role of Olaparib and PARPs in the Cellular Stress Response
Dr Jakub Kopycinski, Nuffield Department of Medicine
Use of High-Definition immune profiling to understand mechanisms underpinning control of high-risk Human Papillomavirus (hrHPV) in exposed women.
Dr Dawn O’Reilly, Department of Oncology
Examine the feasibility of long-range sequencers to build a comprehensive transcriptome isoform blueprint of human breast cancer cells– “a proof of concept” study.
Dr Michael Tellier, Sir William Dunn School of Pathology
Understanding the function of the cyclin-dependent kinase 10 (CDK10) and cyclin M (CycM) in cancer and STAR syndrome, a developmental genetic disease
Prof Ahmed Ahmed, Nuffield Department of Women’s & Reproductive Health
Molecular validation of a putative novel aggressive molecular subtype of ovarian cancer
March 2018
Brian Lyons, Department of Oncology
Use of a mirror image D-amino acid peptide shield to induce immune silencing of an oncolytic virus rendering it hidden to pre-existing neutralising antibodies thus increasing bio-availability and therapeutic efficacy
Abirami Lakshminarayanan, Radiobiology Research Institute, Department of Oncology
Antibody fragments as next generation imaging probes for radiation therapy
Felix Clanchy, Kennedy Institute of Rheumatology
How do IRAK-3 Isoforms contribute to tumour progression?
Akane Kawamura, Department of Chemistry
Targeting the NSD family protein methyltransferases for cancer treatment
Lisa Heather, Department of Physiology, Anatomy and Genetics
Fatty acids as novel metabolic regulators of HIF signalling and hypoxic sensitivity in cancer
Fiona Bangs, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology and The Kennedy Institute of Rheumatology
The impact of the primary cilium on initiation and progression of pancreatic ductal adenocarcinoma
Serena Lucotti, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology
Targeting tumour cell transendothelial migration during metastasis
Richard Bryant, Nuffield Department of Surgical Sciences
Transcriptomics of pre-radiotherapy prostate cancer biopsy samples – a “proof-of-concept” study
Audrey Gerard, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and The Kennedy Institute of Rheumatology
Increasing cancer vaccine efficacy through temporal blockade of IFNg
Peter Holland, Department of Zoology
Assessment of novel Testicular Germ Cell Tumour markers
Adam Cribbs, Botnar Research Centre – Oxford Centre for Translational Myeloma Research
Identifying epigenetic targets to modulate immune checkpoints in the treatment of multiple myeloma
Tim Humphrey, CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology
Binding partners and imaging of the p53-targeting agent RITA
Simon Aldridge, Department of Chemistry
Novel boron-containing 18F tags for PET and bimodal imaging
Hagen Schwenzer, Department of Oncology
Exploring LARP6 as new potential drug target to treat HER2-negative gastric cancer
July 2017
Dr Viktor H. Koelzer, Wellcome Trust Centre for Human Genetics
Prof Tim Maughan, CRUK/MRC Oxford Institute for Radiation Oncology
Expression and polymorphisms of the pattern recognition receptors Stimulator of Interferon Genes (STING) and Toll-like Receptor (TLR) 4 as predictors of disease free survival in the Short Course Oncology Treatment (SCOT) trial of stage II-III colorectal cancer patients.
Mr Puneet Plaha, Oxford University Hospitals NHS Foundation Trust
Mr James Livermore, Department of Neurosurgery
Using night vision goggles to increase the precision of brain tumour surgery
Dr Bart Cornelissen, Department of Oncology
Peptide radionuclide imaging and therapy for pancreatic neuroendocrine tumours
Dr Heidi Olzscha, Department of Oncology
Characterisation of the citrullinome in malignant cell model systems
Dr Alvina G Lai, Professor Jane A McKeating, Target Discovery Institute, Nuffield Department of Medicine
Hypoxic-gene signatures in hepatitis B virus infection that predict hepatocellular carcinoma progression
Dr Vincenzo D’Angiolella, Department of Oncology
A system wide approach to investigate the role of deoxyribonucleotides (dNTPs) in genome stability and cancer cell survival
Dr Richard Owen, Ludwig Cancer Research
An integrative analysis of genomic, proteomic and histology image features in oesophageal metaplasia, dysplasia, and adenocarcinoma.
Dr Enric Domingo, Department of Oncology
Assessment of formalin-fixed paraffin embedded DNA for genome-wide associations studies
Dr Joshua W Owen, IBME
The development of oxygen loaded nanodroplets designed to deliver oxygen under the application of ultrasound for the treatment of tumour hypoxia.
Dr Ole Tietz, Department of Oncology
Intracellular targeting of cancer testis antigens (CTAs) using multimeric cell penetrating peptide (CPPs) clusters
January 2017
Dr John Jacob, Clinical Neuroscience
Dr Vincenzo D’Angiolella, Dr Frances Willenbrock, Oncology
Resolving the significance and mechanism of altered cholesterol metabolism in sonic hedgehog driven medulloblastoma
Prof Catherine Green, WTCHG
SetD3 as a novel target for cancer therapeutics
Prof Alison Banham, NDCLS
Dr Daniel Ebner, TDI
CRISPR Whole Genome Screen to Identify Pathways Driving Expression of the FOXP1 Oncogene
Dr Jia-Ling Ruan, Prof Anne Kiltie, Oncology
Immunomodulation by Gemcitabine-Based Chemoradiation Therapy in Muscle Invasive Bladder Cancer
Prof Simon Leedham, WTCHG
Using somatic mutation to reflect variable underlying disease pathogenesis in colorectal cancer
Dr Imre Mäger, DPAG
The proteome and brain microvascular endothelial cell interactions of brain-metastatic breast cancer extracellular vesicles
Prof Shona Murphy, Dr Justyna Zaborowska, Dunn School
CDK12 at the front line of the DNA Damage Response
Dr Bart Cornelissen, Oncology
Discovery of novel targets to image the effects of irradiation
Dr Gillian Farnie, NDORMS
Prof Claire Edwards, NDS
The influence of bone marrow adipocytes on the activity and dormancy of breast cancer metastasis
Dr Jurgen Brem, Chemistry
Dynamic combinatoria chemistry to develop novel anticancer agents
Prof Panagis Filippakopoulos, SGC
Prof Eric O’Neil, Oncology
Prof Tom Milne, Wimm
BRD4-directed recruitment of NuRD as a potential therapeutic target in cancer
Dr Johanna Michl, Prof Madalena Tarsounas, Oncology
Developing inhibitors of the Fanconi anemia pathway for the treatment of BRCA1/2-deficient cancers
Prof Adam Mead, WIMM
Measuring DNA Damage in Single Cells Using a Novel High Throughput Genomic Assay
Dr Nick Coupe, Oncology
In Vivo investigation of the orphan receptor ROR2 in angiogenesis and bevacizumab sensitivity in BRAF mutant melanoma
Dr Alfredo Castello Palomares, Biochemistry
Decoding the role of the RNA binding activity of p53
Prof Ian Tomlinson, Dr Lennard Lee, WTCHG
Colorectal cancer metastasis signatures and immune profiling of the lymphoid niche – predicting tumour recurrence
Dr Nicola Farrer, Chemistry
Ultrasonic Delivery of Pt(IV) Prodrugs
Dr Annabelle Lewis, Dr Roland Arnold, WTCHG
Identification of drivers of colon cancer cell differentiation: using a validated genomewide CRISPR transcriptional activation screen.
Dr Yanyan Jiang, Dr Anderson Ryan, Oncology
Targeting DNA-PK to selectively potentiate radiosensitivity in a xenograft model of lung cancer by contextual synthetic lethality
Dr Bilyana Stoilova, Prof Paresh Vyas, MHU
Determining the heterogeneity of progenitor phenotypes in human Acute Myeloid Leukaemia
Prof Nicholas La Thangue, Dr Rebecca Miller, Oncology
Dr Weston Struwe, Glycobiology
Heparin sulfate oligosaccharides that bind and inhibit tumourigenic growth have potential as drugs to limit glioma progression
Dr Anjali Kusumbe, Kennedy
Regulation of breast cancer cell metastasis by distinct blood vessel subtypes in the bone marrow microenvironment
Dr Tom McAllister, Dr Akane Kawamura, Chemistry
Cyclic Peptides inhibitors of the IGF/IGF-1R Interaction
Prof Ahmed Ahmed, NDOG
Targeting FER for the treatment of ovarian cancer
June 2016
Prof Kristijan Ramadan, Department of Oncology
Characterization of the SPRTN metalloprotease in DNA-protein crosslinks repair and its potential for cancer therapy
Dr Andrew Protheroe, OUH NHS Foundation Trust
Dr Kilian Huber, SGC
Chemical proteomics to define the kinome of renal cancer and investigate resistance mechanisms to kinase inhibitors
Dr Victor Bolanos-Garcia, Oxford Brookes University
Prof Paul Brennan, SGC
New anticancer therapies through inhibitiion of Anaphase Promoting complex/cyclosome (APC/C) activation by Cdc20
Prof Paul Fairchild, Dunn School of Pathology
Exploiting the epigenetic memory of iPS cells to optimise dendritic cell based vaccinesNew anticancer therapies through inhibitiion of Anaphase Promoting complex/cyclosome (APC/C) activation by Cdc20
Dr Barbara Braden, OUH NHS Foundation Trust
Computer-aided recognition of Barrett’s oesophagus and its early neoplastic changes
Dr Thomas Ashton, Department of Oncology
Study of the anti-malarial, Atovaquone, as an anti-cancer therapeutic
Dr Dimitris Karamitros, MRC Molecular Hematology Unit
Implementation of novel xenotransplantation mouse models for study of human AML LSC
Dr Pavitra Kannan, Dr Benjamin Irving, Department of Oncology
Linking functional MRI with 3D microscopy to assess radiotherapy response in tumour subregions
Prof Deborah Goberdhan, DPAG
Prof Tudor Fulga, WIMM
Proteome and transcriptome of stress-induced cancer exosomes
Dr Ian Gibbs-Seymour, Dunn School of Pathology
Generation of tools to assess a potential new biomarker in breast, ovarian and prostate cancer tissues
Dr Jyothi Menon, Prof Kate Vallis, Department of Oncology
Prof Robert Carlisle, IBME
Ultrasound-responsive nanocomposite hydrogels for treatment of localised chest wall cancer recurrence
Dr Margaret Duffy, Prof Len Seymour, Department of Oncology
Establishing an ex vivo culture platform for slices from freshly-resected human tumours
Dr Jadwiga Nieminuszczy, Department of Oncology
Biochemical characterisation of a novel exonuclease required for homologous recombination as potential target for improving cancer therapy
January 2016
Prof Shoumo Bhattacharya, Cardiovascular Medicine
Targeting the chemokine system in breast and metastatic colon cancer using novel Evasins identified from tick saliva
Prof Colin Goding, Ludwig Cancer Research
Prof Sarah Blagden, Department of Oncology
Translation reprogramming as a therapeutic target in cancer
Dr Bart Cornelissen, Department of Oncology
Prof Veronique Gouverneur, Department of Chemistry
PET Imaging with PARP inhibitors
Dr Oleg Fedorov, Prof Paul Brennan, SGC
Prof Udo Oppermann, NDORMS
Towards development of histone methyl-lysine reader inhibitors for SPIN1- a novel molecular target in liposarcoma
Prof Udo Oppermann, NDORMS
Dr Karthik Ramasamy, OUH NHS Foundation Trust
Tool development to monitor immune suppressive mechanisms by epigenetic inhibitors in multiple myeloma
Dr James Larkin, Prof Nicola Sibson, Department of Oncology
Metabolomic identification of melanoma and lung cancer patients with brain metastases
Dr Simon Lord, OUH NHS Foundation Trust
Dr Neel Patel, OUH NHS Foundation Trust
Dr Anderson Ryan, Department of Oncology
Repurposing cardiac perfusion imaging as a biomarker of anti-angiogenic and antimitochondrial therapy
Dr Benoit Van den Eynde, Ludwig Cancer Research
Developing viral vectored vaccines for MAGE-expressing tumours
Prof Nicholas Lakin, Department of Biochemistry
Identifying novel applications for the use of PARP inhibitors in cancer treatment
Prof Robert Gilbert, STRUBI
Prof Chris Norbury, Dunn School of Pathology
Prof Geoff Higgins, Department of Oncology
Development of improved inhibitors of cytoplasmic uridylyl transferases implicated in multiple types of cancer, including those of unmet need
Dr Eleftheria Dafni Pefani, Dr Eric O’Neill, Department of Oncology
Uncovering the crosstalk between RASSF1A and BLM to target cancer
Dr Yvonne Couch, RDM
Real-time electrical impedance assessment of barrier permeability responses to inflammatory mediators
Dr Catrine Johansson, Department of Chemistry
Structural and functional characterisation of the histone demethylase JMJD1C a potential therapeutic drug target in leukaemia
Dr Judith Nicholson, Prof Anne Kiltie, Department of Oncology
Mapping and validating clinically significant acetylation modifications in the DNA damage response pathway related to radiosensitisation mechanisms
Prof Stephen Faulkner, Department of Chemistry
Dr Bart Cornelissen, Dr Rebekka Hueting, Department of Oncology
Novel 89Zr chemistry for molecular imaging
Dr Lynn Quek, RDM
Lentiviral Barcoding of Primary Human AML Stem Cells
Dr Michael Holmes, Prof Zhenhming Chen, CTSU
Using novel metabolomics profiling for improved risk prediction and understanding of aetiology of pancreatic cancer
Dr Mariolina Salio, Prof Enzo Cerundolo, MRC Human Immunology Unit
Analysis of the T Cell repertoire in bladder cancer
Dr Ronan Broderick, Department of Oncology
Exploiting the potential on a novel human exonuclease required for homologous recombination in cancer therapy
Dr Richard Hopkinson, Department of Chemistry
Investigating the Molecular Mechanisms of Formaldehyde-induced Carcinogenicity
Prof Richard Gibbons, Dr Dennis Ptchelkine, WIMM
Determining the structure of the ATRX tumour suppressor complex
June 2015
Dr Omer Dushek, Sir William Dunn School of Pathology
Phenotypic models of chimeric antigen receptors for cancer therapy
Dr Tim Humphrey, CRUK / MRC Oxford Institute for Radiation Oncology
Determinants of histone H3K36Me3 loss and tumorigenesis
Dr Bostjan Markelc, CRUK / MRC Oxford Institute for Radiation Oncology
Understanding the blood flow and sprouting angiogenesis in tumours via a multidisciplinary approach based on mathematical modelling and 3D in vivo imaging
Dr Valentine Macaulay, Dr Tamara Aleksic, Department of Oncology
Investigating the clinical-translational significance of nuclear IGF-1R
Prof Peter McHugh, Department of Oncology
Prof Jan Rehwinkel, Weatherall Institute of Molecular Medicine
Prof Adrian Harris, Department of Oncology
Investigating how the therapeutic DNA damage induces and antiviral state and the role of CDK8, a druggable kinase, in mediating this process
Dr James Franklin, CRUK & EPSRC Cancer Imaging Centre in Oxford
Genomic characterisation of imaging phenotypes in colorectal liver metastases
Dr Fiona Larner, Department of Earth Sciences
High Precision Zinc Isotopic Compositions in Breast Cancer
Dr Michael McDonough, Department of Chemistry
Hypoxia-Inducible Factor-Independent Roles of the Major Kidney Tumour Suppressor von Hippel-Lindau Protein
Dr Clare Verrill, Nuffield Department of Surgical Sciences
Evolution of prostatic adenocarcinoma to neuroendocrine (small cell) carcinoma after hormonal or radiotherapy as a therapy resistance mechanism: a pilot next generation sequencing and immunohistochemical study
Dr Katarzyna Leszczynska, Prof Ester Hammond, CRUK / MRC Oxford Institute for Radiation Oncology
Investigation of hypoxia-regulated p53 function in cancer through its novel downstream target, LGR6
Dr Martin Cohn, Department of Biochemistry
The Fanconi Anemia FANCD2/FANCI protein complex as a potential therapeutic cancer target
Dr Whitney Kellett, Prof James McCullagh, Department of Chemistry
Supercritical fluid chromatography-mass spectrometry metabolomics of glioblastoma
Prof Panagis Filippakopoulos, Structural Genomics Consortium
ZMYND8-regulation of MITF as potential therapeutic target in melanoma
Dr Eric O’Neill, Department of Oncology
Dr Szele, Department of Physiology, Anatomy & Genetics
Degregulation of Neuronal Stem Cells and Glioma Development
January 2015
Dr Samantha Hughes, Dr Aziz Aboobaker, & Dr Nobu Kosaka Department of Zoology
An Invertebrate Model to Investigate the Molecular Mechanisms Regarding Sensitivity to Radiation
Dr Roman Fischer & Dr Matthew Cockman, Nuffield Department of Clinical Medicine
Dr Sarah Larkin Nuffield Department of Clinical Neurosciences
Defining the Deep Hypoxia Proteome in Cancer – a Space & Tissue Resolved Case Study on Brain Tumours
Professor Michael Chappell Institute of Biomedical Engineering
DoxCEST:Non-invasive monitoring of targeted chemotherapeutic doxorubicin delivery using Chemical Exchange Saturation Transfer MRI
Dr Su Yin Lim & Professor Ruth Muschel CRUK / MRC Oxford Institute for Radiation Oncology
Angiopoietin-like protein 7 (ANGPTL7) expression in colorectal cancer liver metastasis
Dr Sarah Wordsworth & Dr Paul Hewitson Nuffield Department of Population Health
Could adding genetics to the Bowel Cancer Screening Programme be an acceptable and cost-effective option for the NHS?
Professor Fiona Powrie, Ms Sarah McCuaig, Dr Nathan West Kennedy Institute
Professor Tim Maughan Department of Oncology
IL-22 signalling and KRAS mutation synergize to promote malignancy and poor prognosis in colorectal cancer
Dr Madalena Tarsounas CRUK / MRC Oxford Institute for Radiation Oncology
Targetting BRCA2 deficiency with GSK3 inhibitors
June 2014
Dr Akane Kawamura & Dr Christoph Loenarz, Department of Chemistry
TET inhibitors: probes for DNA modifications in oncology
Dr Anderson Ryan, Department of Oncology
In vivo whole genome shRNA screen to identify novel targets for radiosensitisation
Dr Brian Marsden & Mr Michael O’Hagen, Structural Genomics Consortium
Exploring the breadth of chemical biology at Oxford: a symposium by ChemBio Hub to strengthen interdepartmental research connections
Dr Chris Yau, Wellcome Trust Centre for Human Genetics
Statistical methods for integrating single-cell RNA sequencing with single-cell imaging analysis for the study of cancer therapy resistant stem cells
Dr Irina Redchenko, The Jenner Institute
Pre-clinical efficacy evaluation of the vectored vaccine with PD1 monoclonal antibody as a combination immunotherapy for prostate cancer
Dr Ross Chapman, Wellcome Trust Centre for Human Genetics
Molecular characterisation of a novel function of the 53BP1 protein in tumour suppression
Dr Kristijan Ramadan & Dr Ignacio Torrecilla, Department of Oncology
Dynamics of p97/VCP interactome after ionizing radiation
Dr Lucy Dorrell, Nuffield Department of Medicine
Development of novel viral vectored multi-genotype vaccines for therapy of human papillomavirus infections (HPV).
Dr Panagis Filippakopoulos, Structural Genomics Consortium
Professor Sir Walter Bodmer & Professor Tim Maughan, Department of Oncology
Role of bromo and extra-terminal (BET) proteins in colorectal cancer
January 2014
Professor Adrian Harris, Dr Alan McIntyre, Dr Daniel Ebner & Dr Geoff Higgins, Department of Oncology
The epigenetics of breast cancer and response to hypoxia
Dr Bart Cornelissen & Dr Somnath Mukherjee, Department of Oncology
Molecular imaging biomarkers of gemcitabine resistance in advanced mouse models of pancreatic adenocarcinoma
Dr Benjamin Fairfax, Wellcome Trust Centre for Human Genetics
Investigating human variation in ATM expression, functional outcomes and relationship to Metformin response
Professor Colin Goding, Ludwig Cancer Research
Professor Mark Middleton, Department of Oncology
Generating melanoma-initiating cells and pre-clinical testing a novel anti-melanoma agent
Dr Ester Hammond & Dr Somnath Mukherjee, Department of Oncology
Preclinical testing of novel therapy combinations for oesophageal cancer
Professor Katherine Vallis, Department of Oncology
Dr Sonia Trigueros, Department of Physics
The Application of Nanotechnology to Oncology: The Smart NanoSystem
Dr Svetlana Khoronenkova, Department of Oncology
X-‐linked mental retardation syndrome: deficiency in the DNA damage response
Dr Simon Leedham, Wellcome Trust Centre for Human Genetics
Clonal diversity as a biomarker of cancer progression in resected colorectal polyps
Professor Vincenzo Cerundolo & Dr Simon Davis, Radcliffe Department of Medicine
Professor Mark Middleton, Department of Oncology
Professor Tim Maughan, CRUK MRC Oxford Institute for Radiation Oncology
Combined use of radiotherapy and PD1 blocking antibodies to enhance tumour specific immune responses
June 2013
Dr Anne Kiltie, CRUK MRC Oxford Institute for Radiation Oncology
Pre-clinical testing of panobinostat as a radiosensitising agent in bladder cancer
Dr Adam Mead, Nuffield Division of Clinical Laboratory Sciences
Unravelling clonal complexity in myelofibrosis stem cells though application of single cell transcriptomics
Dr David N Church, Department of Oncology
Pilot evaluation of digital PCR and tagged amplicon sequencing to assess circulating tumour DNA in patients with metastatic melanoma and colorectal cancer
Dr Daniel Whalen, Dr Claire Palles & Professor Ian Tomlinson, Nuffield Department of Medicine
Structural and biochemical characterisation of human DNA polymerase epsilon and cancer-‐associated variants
Dr Geoff Higgins, Dr Nick de Pennington & Dr Nicola Sibson, Department of Oncology
Development of primary cell culture facilities in neuro-oncology
Dr Peter McHugh & Professor Adrian Harris, Department of Oncology
Specific killing of Fanconi anemia deficient Cancer cells with a Cdk inhibitor – a preclinical analysis prior to phase I development
Dr Tim Humphrey & Dr Anderson Ryan, CRUK MRC Oxford Institute for Radiation Oncology
Preclinical validation of a breakthrough therapy for SETD2-deficient cancers
Dr Tatjana Sauka-Spengler, Radcliffe Department of Medicine
Developing a zebrafish model for regulatory profiling of cancer cell subpopulations
Dr Vincenzo D’Angiolella, Department of Oncology
Regulation of dNTP pools homeostasis during the DNA damage response
January 2013
Dr Anne Kiltie, CRUK MRC Oxford Institute for Radiation Oncology
Radiosensitising effects of histone deacetylase inhibitors: preclinical biomarker development in bladder cancer
Dr Eric O’Neill & Dr Simon Scrace, CRUK MRC Oxford Institute for Radiation Oncology
Personalised therapeutic targeting of tumours
Dr Francisco Perez-Balderas & Dr Nicola Sibson, Department of Oncology
Targeting angiogenesis: novel particulate systems for advanced treatment of cancer
Dr Martin Cohn, Department of Biochemistry
Characterization of novel FANCD2-‐interacting proteins
Dr Patrick John Pollard, Nuffield Department of Medicine
A Functional Genetic Screen in a Novel Model of Fumarate Hydratase Deficiency
Dr Ricky Sharma, Department of Oncology
Discovery of drugs to sensitise cancer cells and hepatic stellate cells to radiotherapy
Dr Sébastien Serres, CRUK MRC Oxford Institute for Radiation Oncology
Development of quantitative pH‐imaging to study tumour microenvironment in Medulloblastoma
Dr Remko Prevo & Dr Geoff Higgins, Department of Oncology
A compound screen to identify novel sensitisers for radiation and platinum treatment in lung cancer
June 2012
Dr Alex Bullock & Dr Georgina Kerr, Structural Genomics Consortium
New strategies to circumvent resistance to VEGF inhibition in tumour angiogenesis
Dr Benjamin Fairfax, Wellcome Trust Centre for Human Genetics
Mutation detection in circulating DNA to assess disease burden and progression in Renal Cell Carcinoma
Dr Deborah Goberdhan & Dr Clive Wilson, Department of Physiology, Anatomy and Genetics
Dr Claire Edwards & Dr James Edwards, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences
Professor Adrian Harris, Department of Oncology
Professor Ian Sargent, Nuffield Department of Obstetrics & Gynaecology
Professor Freddie Hamdy, Nuffield Department of Surgical Sciences
Dissecting the Regulation and Functions of Tumour Cell Exosomes
Professor David Vaux, Sir William Dunn School of Pathology
Dependence of the mutation burden in mitochondrial DNA on the expression of functional BRCA1
Dr Emily Flashman, Department of Chemistry
Histone Demethylase Activity in Hypoxia
Dr Holm Uhlig, Experimental Medicine Division
Immune dysregulation in patients with PTEN hamartoma tumor syndrome
Professor Sir Michael Brady, Department of Oncology
Biomechanics and Elastography of breast tumours
Dr Nadia Falzone, Department of Oncology
Development of robust experimental models to evaluate the effect of heterogeneous distribution of targeted radiotherapeutics
Dr Naomi Sharma & Professor Freddie Hamdy, Nuffield Department of Surgical Sciences
Dr Anne Kiltie, CRUK MRC Oxford Institute for Radiation Oncology
Novel pre-clinical models and imaging techniques in urological malignancies
Dr Stephen Kearsey, Department of Zoology
Using laser ablation to study recruitment of repair factors to sites of DNA damage
Dr Svetlana Khoronenkova, Department of Oncology
Role of the E3 ubiquitin ligase Mule in the DNA damage response: links to carcinogenesis sites of DNA damage
Dr Simon Leedham & Professor Ian Tomlinson, Wellcome Trust Centre for Human Genetics
Use of Next-Generation Sequencing to Investigate the Evolution Of Sub-Clones Within Colorectal Tumours
Dr Valentine Macaulay, Department of Oncology
Dr Gareth Bond, Nuffield Department of Medicine / Ludwig Cancer Research
The evaluation of IGF-1R as a biomarker for treatment response to DNA damaging cancer therapies
Professor Xin Lu, Ludwig Cancer Research
Dr Olaf Ansorge, Department of Neuropathology and Ocular Pathology
Investigating a potential role of the ASPP proteins in anti-EGFR mediated cancer therapy: Molecular characterisation of the Oxford Glioma Cohort
Dr Gareth Bond & Professor Ian Tomlinson, Nuffield Department of Medicine / Ludwig Cancer Research
Transcriptional control of p21 and its relationship to colorectal cancer susceptibility
January 2012
Dr Aaron Leiblich, Nuffield Department of Surgical Sciences
Dissecting the Complex Biology of Prostate Cancer Cells Using the Novel Drosophila Accessory Gland Model
Dr David N Church, Department of Oncology
Mechanistic and biomarker evaluation of FBW7 mutation in colorectal and endometrial cancers
Dr Helen Townley, Department of Engineering Science
Spectrofluorometer to monitor both powders and liquid samples
Dr James McCullagh, Department of Chemistry
Towards Isotopic Biomarkers for Cancer: A novel application
Dr Norma Masson, Nuffield Department of Medicine
Assessment of the role of BPGM in cancer cell metabolism
Dr Philip Simister & Dr Stephan Feller, Weatherall Institute of Molecular Medicine
Targeting an ‘Achilles heel’ in the molecular signal computation of cancer cells
Dr Simon Leedham, Wellcome Trust Centre for Human Genetics
Investigating the mechanism and consequences of derangement of tissue-specific GREMLIN1 expression in familial and sporadic colorectal carcinogenesis
June 2011
Dr Gareth Bond, Nuffield Department of Medicine / Ludwig Cancer Research
The identification and characterisation of single nucleotide polymorphisms (SNPs) in 14-3-3tau and CD44 that affect human cancer
Dr Nadia Falzone, Department of Oncology
Demonstration of nano-scale 3-D visualization of dose patterns from radionuclides used for targeted cancer therapeutics using chemically enhanced resists
Dr John Fox, Department of Engineering Science
Advanced information technology to support decision-making in the breast cancer multi-disciplinary meeting
Dr Deborah Goberdhan, Department of Physiology, Anatomy and Genetics
Characterisation of Proton-Assisted Amino Acid (PAT/SLC36) Transporter Function in Cellular Resistance to Microenvironmental Stress During Tumorigenesis
Dr Eric O’Neill, CRUK MRC Oxford Institute for Radiation Oncology
Analysis of SNPs in tumour suppressor regulatory genes that affect outcome in the COIN trial.
Dr Milap Rughani, Department of Oncology
Inhibition of the Phosphatidylinositol-3 Kinase pathway in melanoma cells in relation to senescence
Dr Pamela Sivathondan, Nuffield Department of Surgical Sciences / Nuffield Department of Obstetrics and Gynaecology
The development of a 3D primary human hepatocyte and liver stem cell culture system to study hepatocyte dysfunction and strategies for resuscitation in vitro
Dr Pawel Swietach, Department of Physiology, Anatomy and Genetics
Implementing a high‐throughout assay to measure intracellular and membrane‐bound carbonic anhydrase activity in cancer cells
Mr Stuart Winter, Ear, Nose and Throat
Dr Stephan Feller, Department of Oncology
High-throughput screen for novel drug combinations targeting head and neck squamous carcinomas
January 2011
Dr Anne Kiltie, CRUK MRC Oxford Institute for Radiation Oncology
Collection and storage of bladder normal tissue and cancers (CASABLANCA)
Dr Anthony Kong, Department of Oncology
To investigate the resistance mechanisms of targeted therapies and to assess the HER2 dimerisation states of circulating tumour cells in non-HER2 over-expressed breast cancer in comparison to the HER2 over-expressed breast cancer cell lines and xenograft models
Dr Claire Edwards, Nuffield Department of Surgical Sciences
Adipokines in Prostate Cancer Bone Metastases
Dr Ester Hammond, Department of Oncology
Development and in vivo testing of bio-reductive replication inhibitors
Dr Kevin Myers, Department of Oncology
Biomarker development in Cancer Clinical Trials
Dr Coleman, Nuffield Department of Medicine
Cellular Studies of Cancer-associated ribosomal hydroxylases, MINA53 and NO66
Dr Leake, Department of Physics / Department of Biochemistry
Investigating cancer in living human cells using ultrasensitive single molecule optical microscopy
Professor Chetty, Nuffield Division of Clinical Laboratory Sciences
Quantitative imaging in molecular pathology
Dr Sharma, Department of Oncology
Pharmacological lethality with ionising radiation: Development of an innovative high-throughput assay for drug discovery
Dr Feller, Department of Oncology
Development of SH2 domains as probes for monitoring cancer drug activities in trials
