Colorectal Cancer Working Group

Working Group Membership

The CRC Working Group is made-up of several Centre members from across the University and OUH NHS Foundation Trust. It also draws in expertise from those working on the S-CORT Consortium.

S-CORT Consortium

The £5M Stratification in COloRecTal cancer or S-CORT Consortium is made up of the following partners: University of Oxford; Queen’s University Belfast; University of Birmingham; University of Leeds; Wellcome Trust Sanger Institute; MRC Clinical Trials Unit; Kings College London; University of Aberdeen; University College London; Almac; Astra Zeneca; Glaxo Smith Kline; Beating Bowel Cancer; Northern Ireland Cancer Research Consumers Forum; European Organisation for Research and Treatment of Cancer; Cardiff University; Ku Leuven; European Alliance for Personalised Medicine; The University of Manchester; European Cancer Organisation. The funding for S-CORT is split evenly between Cancer Research UK and the Medical Research Council.

S-CORT will use the latest genome-based technology to uncover the complex biology of bowel cancer in samples collected from over 2,000 patients from large clinical trials. Researchers will use this information to precisely match the right treatment to the right patient. This approach will help better predict how different patients respond to treatment, allowing the most effective therapies to be delivered to newly-diagnosed bowel cancer patients.

These insights should help doctors decide which patients receive the chemotherapy drug oxaliplatin, what type of radiotherapy they’re offered, and may also help surgeons to remove as little of the bowel as possible.

More than 41,500 people are diagnosed with bowel cancer each year in the UK and treatment varies based on the type and size of the tumour, whether the disease has started to spread (metastasise), and on the health and fitness of each patient. This programme of research will identify and use new ways to predict the patient’s response to treatment based on the genetic make-up of their tumour, as well as helping doctors decide how to treat patients more effectively.

Be part of the Colorectal Cancer Working Group

We are always keen to welcome new members to our working groups, and value contributions from those working in disciplines not traditionally linked to cancer research. If you want to find out more about colorectal cancer research, have some research that you think may be of interest to this group, or would like to make connections within this community then please get in touch with the Cancer Research UK Oxford Centre team on cancercentre@oncology.ox.ac.uk