What is your current research?
For my DPhil project, I’m interested in understanding the role of DNA modifications in normal and malignant haematopoiesis, and I’d like to illustrate the molecular mechanism of DNA modification function in cancer development.
Cytosine in DNA are chemically modified into 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC),5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). 5mC and 5hmC are stable modifications which are involved in gene regulation. Importantly, cancer cells display abnormal DNA modification profile and develop the CpG island methylator phenotype, which could function as a biomarker for early detection and response to therapy.