Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group

The causes of prostate cancer are not well understood, and therefore there is little that men can do to reduce their risk. EHNBPCCG aim to identify factors which affect risk, particularly of the more aggressive forms of the disease, with the aim of developing strategies for prevention. The group was established in 2004 with its secretariat in the Cancer Epidemiology Unit, and it is co-directed by Prof Tim Key and Associate Professor Naomi Allen.

EHNBPCCG conducts pooled analyses of endogenous hormones and nutritional biomarkers in relation to prostate cancer risk. For most biomarkers, there is sufficient statistical power to analyse the associations subdivided by disease aggressiveness and other patient characteristics, which cannot be done in any one individual cohort study. Scientists from 39 studies worldwide are collaborating in this work. So far, the project has collected data from around 36,000 men with prostate cancer and over 56,000 control men. These samples have been interrogated for more than 50 biomarkers.